“Afresh” is an adverb and perhaps the closest is Spanish is “de nuevo” or “otra vez”.

Sometimes mortals decide to do things afresh (volver a hacer), to start to do something from the beginning a second time, or start “life afresh”.

At other times people want to start something or their life afresh (volver a empezar/empezar de nuevo).

Some examples:

  • Each day is an opportunity to start afresh (…comenzar de nuevo).
  • Perhaps now is the time to look at the matter afresh (quizás es el momento de volver a examinar la cuestión.
  • I want the chance to walk away from the mess and start afresh.