“To meddle” is to interfere (entremeterse o estorbar) with something) or to tamper with something. The context is usually negative. Contemplate these:
- Who asked you to meddle in my affairs (asuntos) or matters (¿Quién te manda a ti meterte en mis asuntos?)?
- Mr. Sanchez is always meddling (estropeando) in the economy.
- Why are you meddling with my flower arrangement?
A person who meddles is a “meddler” (un entrometido), and the person´s actions are meddlesome.